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The study highlighted that patients reported their experiences with over 150 treatments, identifying those with the greatest perceived benefits for core symptoms like post-exertional malaise (PEM)

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in preclinical models it activates the VEGFR2-Akt-eNOS signaling axis to promote angiogenesis and tissue vascularization ( It also engages ERK1/2 and FAK-paxillin pathways that regulate endothelial cell migration and fibroblast activity, and upregulates heat shock proteins (HSP70/90) for cytoprotective effects in gastrointestinal tissue models ( Research across multiple rodent injury models has characterized its activity in tendon, muscle, nerve, and GI tissue contexts

doi:10.1016/0014-2999(93)90997-V 51